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SERENADE

Sensor-based explainable detection of cognitive decline

Introduction to the pilot

Context: Mild Cognitive Impairment (MCI) can progress to dementia, resulting in impaired cognitive function as well as decreased work, social, and relational abilities.

Problem: Sporadic visits with medical experts can not accurately assess the cognitive decline, which often consists of subtle behavioral changes.

Solution: We are developing a solution for continuous behavioral remote monitoring at home, so to identify digital biomarkers for early detection of cognitive decline

Objective: To enable clinicians inspecting potential indicators of cognitive decline and improving their diagnosis. 

Senior Man on a bridge using Smart Watch measuring heart rate

Objectives

600000
MCI patients in Italy
0
Millions of people with dementia worldwide
0
Millions of new cases of dementia each year
0
Millions of Euros: annual cost of dementia​

Timeline

Kick-off meeting
September 2022
The SERENADE project is started

The multidisciplinary team (composed of neurologists, neuropsychologists and computer scientists) meets to project schedule and specific objectives. The team starts analyzing the cognitive decline indicators required by the clinicians and how to capture them with unobtrusive sensing technologies.

Design and testing
Winter 2023
Design and testing of data collection infrastructure

We design a robust sensing infrastructure capable of capturing the activities and the cognitive decline indicators required by the clinician. This infrastructure has been extensively tested in the lab.

Ethical Committee approval
Spring 2023
Project proposal approved by Ethical Committee

Our unobtrusive sensing solution to detect early indicators of cognitive decline was approved by the ethical committee.

Preliminary experiments
Spring 2023
Preliminary experiments with a conversational assistant

Our sensing infrastructure includes a smart cognitive assistant (i.e., a tablet application) to evaluate the cognitive status of the patient with specifically designed tests. We performed a preliminary experiment with real MCI patients in the hospital.

Deployments and start of data collection
Summer 2023
SERENADE data collection in patients' homes

We start installing the sensing infrastructure in the homes of the enrolled patients and start acquiring data.

Smart Monitoring of Daily Life
June 2024 - Now
Data analysis
We are continuously analyzing data coming from the 20 homes from which we are collecting data. This also involves designing and refining algorithms to find significant behavioral changes from many different dimensions (e.g., sleep, nutrition, Activities of Daily Living).
Prototype for Clinical Behavior Monitoring
June 2024 - Now
Dashboard for the clinicians

We implemented the first prototype of a web application that will allow clinicians to monitor the results of our analysis for each patient, including the detected behavioral changes.
We plan to conclude this implementation by the end of 2025 and to deploy it in the hospital domain.

Integration with the telemedicine system
Validation and refinement

System components

Each patent will be monitored thanks to a combination of unobtrusive environmental sensors (installed in the home infrastructure), mobile, and wearable devices. This sensing infrastructure generates a continuous sensor data stream that is stored in a gateway inside the home.

AI algorithms will analyze collected sensor data to identify and monitor human activities, sleep and movement patterns considered as relevant indicators of behavioral changes. 

SERENADE will include a graphical interface for clinicians, that will show the output of our AI algorithm in a clear and explainable way as a decision support tool for their diagnosis.

The pilot’s goal is to integrate the decision support system in a telemedicine platform. This will facilitate the storage and management of sensible data, its analysis in an anonymous form, and the interaction with the regional health service, including booking and accounting of the proposed service.

Team

Claudio Bettini

Pilot Co-Leader
Dept. of Computer Science

Daniela Galimberti

Pilot Co-Leader
Dept. of of Biomedical, Surgical and Dental Sciences

Gabriele Civitarese

Pilot co-Leader - AI Specialist
Dept. of Computer Science

Andrea Arighi

Neurologist - Study Coordinator
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Emanuela Rotondo

Neuro-Psychologist
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Vittoria Borracci

Neuro-Psychologist
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

Publications

Comparing self-supervised learning techniques for wearable human activity recognition, Sannara Ek, Riccardo Presotto, Gabriele Civitarese, François Portet, Philippe Lalanda & Claudio Bettini , CCF Trans. Pervasive Comp. Interact, 2025 Publication

Large Language Models are Zero-Shot Recognizers for Activities of Daily Living, Gabriele Civitarese, Michele Fiori, Priyankar Choudhary and Claudio Bettini, ACM Transactions on Intelligent Systems and Technology, 2025 Publication

Multi-subject human activities: A survey of recognition and evaluation methods based on a formal framework, L. Arrotta, G. Civitarese, X. Chen, J. Cumin, C. Bettini. , In: EXPERT SYSTEMS WITH APPLICATIONS. - ISSN 0957-4174. - 267:(2025 Apr), pp. 12617, 2025 Publication

ContextGPT: Infusing LLMs Knowledge into Neuro-Symbolic Activity Recognition Models, L. Arrotta, C. Bettini, G. Civitarese, M. Fiori, In: 2024 IEEE International Conference on Smart Computing (SMARTCOMP)[s.l] : IEEE, 2024. - ISBN 979-8-3503-4994-8. - pp. 55-62, 2024 Publication

Semantic Loss: A New Neuro-Symbolic Approach for Context-Aware Human Activity Recognition, Luca Arrotta, Gabriele Civitarese & Claudio Bettini, Proceedings of the ACM on Interactive, Mobile, Wearable and Ubiquitous Technologies, Volume 7, Issue 4 Article No.: 147, Pages 1 - 29, 2024 Publication

Using Large Language Models to Compare Explainable Models for Smart Home Human Activity Recognition, M. Fiori, G. Civitarese, C. Bettini, In: UbiComp '24 / [a cura di] V. Kostakos, J. Kay, T. Hoang. - [s.l] : ACM, 2024 Oct 05. - ISBN 979-8-4007-1058-2. - pp. 881-884 (( convegno International Joint Conference on Pervasive and Ubiquitous Computing tenutosi a Melbourne nel 2024 [10.1145/3675094.3679000]., 2024 Publication

Is Querying Users Acceptable for Human Activity Recognition Based on Active Learning?, R. Presotto, G. Civitarese, C. Bettini, In: 2023 IEEE International Conference on Pervasive Computing and Communications Workshops and other Affiliated Events (PerCom Workshops)[s.l] - ISBN 978-1-6654-5381-3. - pp. 521-526 , 2023 Publication

SelfAct: Personalized Activity Recognition based on Self-Supervised and Active Learning, Luca Arrotta, Gabriele Civitarese, Samuele Valente, Claudio Bettini, 20th EAI International Conference on Mobile and Ubiquitous Systems: Computing, Networking and Services, November 14-17, 2023 Melbourne, Australia., 2023 Publication

DOMINO: A Dataset for Context-Aware Human Activity Recognition using Mobile Devices, Arrotta, Luca; Civitarese, Gabriele; Presotto, Riccardo; Bettini, Claudio, UNIMI Dataverse, V3, 2023 Dataset

DOMINO: A Dataset for Context-Aware Human Activity Recognition using Mobile Devices, Luca Arrotta, Gabriele Civitarese, Riccardo Presotto, Claudio Bettini, In Proceedings of the 24th International Conference on Mobile Data Management (MDM), IEEE Computer Society, 2023 Publication

SmartFABER: Recognizing Fine-grained Abnormal Behaviors for Early Detection of Mild Cognitive Impairment, Daniele Riboni, Claudio Bettini, Gabriele Civitarese, Zaffar Haider Janjua, Rim Helaoui., Artificial Intelligence in Medicine, Elsevier, 2016 Publication

Combining Public Human Activity Recognition Datasets to Mitigate Labeled Data Scarcity, Riccardo Presotto, Sannara Ek, Gabriele Civitarese, François Portet, Philippe Lalanda, Claudio Bettini, In 2023 IEEE International Conference on Smart Computing (SMARTCOMP), 2023 Publication

The MARBLE dataset: Multi-Inhabitant Activities of Daily Living combining Wearable and Environmental Sensors Data, Arrotta, Luca; Civitarese, Gabriele; Bettini, Claudio, UNIMI Dataverse, V1, 2021 Dataset

Probabilistic Knowledge Infusion through Symbolic Features for Context-Aware Activity Recognition, Luca Arrotta, Gabriele Civitarese, Claudio Bettini, Pervasive and Mobile Computing, Elsevier, 2023. (DOI: 10.1016/j.pmcj.2023.101780), 2023 Publication